There was also one confirmed fatality on the ground after the craft went down at about 10:20 p.m. Eastern time in Clarence Center, about seven miles from Buffalo-Niagara International Airport, according to CNN. The flight was en route from Newark, N.J.
Dozens followed the news on Twitter and posted personal reactions, including @gregfinn, who was flying into Buffalo on a later flight.
@gregfinn (New York): The plane in front of mine arriving in Buffalo crashed, probably no survivors. Thoughts are with those all those families & friends
@gregfinn (New York): There were two of the cutest kids ever that looked to be waiting for their dad, I hope he was on my flight
@gregfinn (New York): My plane landed in Buffalo 9 minutes after the crash, there was no ice or anything at all that I saw, the visibility was horrible tough
For those living in the Buffalo area, the tragedy had a direct impact.
@DragonFire1024 (Buffalo, N.Y.): flt 3407 was the same plane I took to & from Newark when I went to NH for Xmas and New Years. I thought about about the ice I saw on it too
@allisonwilton (Buffalo, N.Y.): still in shock about the plane crash...a girl who works at guest service lost her father who was on the plane :(
@RITBeast (Cheektowaga, N.Y.): Hoping I don't know anyone in the plane crash.
Others, not as close to the action, watched the story unfold on live news.
@BryanKersey (Valdosta, Ga.): OMG So horrible plane crash in Buffalo NY, Watching on CNN now. There is fire everywhere. CNN "Not much of plane exists"
@BryanKersey (Valdosta, Ga.): CNN "Plane Crashed Into House" Such a shock & so sad after the miracle that happened a few weeks ago.
@BryanKersey (Valdosta, Ga.): Such a tragedy & the day before Valentine's Day.
But the majority of those stopping at Twitter to take in the news merely used their 140 characters to send prayers and good wishes.
@amandashelburne (Long Beach, Miss.): Going to bed now. Please lift up a prayer for the family and friends of those lost in tonight's plane crash in Buffalo!! Goodnight Twitter.
@annaosgoodby (Eugene, Ore.): my prayers go out to the 49 killed in plane crash near buffalo
@TheMacMommy (Tucson, Ariz.): sending prayers & thoughts to family & friends of Buffalo New York plane crashed that killed 49. Life is too short. Say I Love You everyday.